11 TCA
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![](https://photos.thisispiggy.com/file/wikiFiles/D9E8AE9D-3204-4CA5-AC09-080BB4F04AC3.jpg)
![](https://photos.thisispiggy.com/file/wikiFiles/B65FE2AB-DF16-4C36-9EFF-FDF0AD18E069.jpg)
- products used where they are produced
![](https://photos.thisispiggy.com/file/wikiFiles/19F6E0E9-C078-48FF-ABEA-B1A63D41FFF1.jpg)
- acetyl coa donates 2 C to TCA that are removed as 2 CO2, no net difference in carbons
- acetyl coa cannot be converted to glucose that's made from oxaloacetate because it doesn't donate any extra carbons
- even chain FA can be converted to acetyl coa, cannot increase oxaloacetate or make glucose
Citrate
![](https://photos.thisispiggy.com/file/wikiFiles/6B362BF9-9C84-41BB-9990-80F465D942D0.jpg)
- irreversible, regulated by ATP
- citrate important indicator of energy levels inside cell. High levels of ATP inhibits citrate metabolism
![](https://photos.thisispiggy.com/file/wikiFiles/E440A483-D26E-48D8-BD11-E962E21E3706.jpg)
- lowers level of oxaloactate for citrate synthase = less acetyl coa used
- high acetyl coa also from FA oxidation
- result: shunted towards ketone
Isocitrate
![](https://photos.thisispiggy.com/file/wikiFiles/A92C4486-A68E-433E-B610-EDEFB4B8C9F5.jpg)
A Ketoglutarate
![](https://photos.thisispiggy.com/file/wikiFiles/86E50DE1-B710-4E07-B4B0-2558DFCF09ED.jpg)
Succinyl
![](https://photos.thisispiggy.com/file/wikiFiles/1DE5FB75-1348-49FF-AF40-1F4EE01111A0.jpg)
- irreversible
- succinyl coa/NADH inhibit
Succinate
![](https://photos.thisispiggy.com/file/wikiFiles/B01546A2-2E85-4D36-9B29-E32FCEED62FC.jpg)
Fumarate
![](https://photos.thisispiggy.com/file/wikiFiles/70145D75-3B78-495C-A6BD-5F9BEF59AFEE.jpg)
![](https://photos.thisispiggy.com/file/wikiFiles/CACBFD65-107F-4E04-8B64-1CD7DD17C47D.jpg)
Malate
![](https://photos.thisispiggy.com/file/wikiFiles/1261827B-DAAF-447C-9E4F-E9AC84240B8E.jpg)
![](https://photos.thisispiggy.com/file/wikiFiles/83812596-71EC-40DA-B610-EEE4A4CA05E8.jpg)
- transport NADH in for ETC and oxaloacetate out for gluconeogenesis
![](https://photos.thisispiggy.com/file/wikiFiles/E08229BD-1198-40C6-B6C1-C9EED3601C6D.jpg)
- donate electron from NADH to malate
- OAA regenerated outside via aspartate conversion
![](https://photos.thisispiggy.com/file/wikiFiles/E6DEFF86-01BA-4FF1-8EBE-B65670B9634E.jpg)
![](https://photos.thisispiggy.com/file/wikiFiles/6F80AB0F-913C-447A-ABEB-ED5679D32C91.jpg)
![](https://photos.thisispiggy.com/file/wikiFiles/257F73E2-5A44-412F-B5A1-FB4C0A10887B.jpg)
![](https://photos.thisispiggy.com/file/wikiFiles/4B37EEF3-F5DA-40ED-9CD9-C0495564B074.jpg)
![](https://photos.thisispiggy.com/file/wikiFiles/52CC9C8C-AB90-466E-9559-2E6E5D704C46.jpg)
![](https://photos.thisispiggy.com/file/wikiFiles/384C9430-D397-431B-A75D-0AB086C273E5.jpg)
![](https://photos.thisispiggy.com/file/wikiFiles/233FE4B1-FFFC-400D-A33F-5CF6D9F9C2CC.jpg)
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