11 TCA
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- products used where they are produced
- acetyl coa donates 2 C to TCA that are removed as 2 CO2, no net difference in carbons
- acetyl coa cannot be converted to glucose that's made from oxaloacetate because it doesn't donate any extra carbons
- even chain FA can be converted to acetyl coa, cannot increase oxaloacetate or make glucose
Citrate
- irreversible, regulated by ATP
- citrate important indicator of energy levels inside cell. High levels of ATP inhibits citrate metabolism
- lowers level of oxaloactate for citrate synthase = less acetyl coa used
- high acetyl coa also from FA oxidation
- result: shunted towards ketone
Isocitrate
A Ketoglutarate
Succinyl
- irreversible
- succinyl coa/NADH inhibit
Succinate
Fumarate
Malate
- transport NADH in for ETC and oxaloacetate out for gluconeogenesis
- donate electron from NADH to malate
- OAA regenerated outside via aspartate conversion
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